''Hati'', Awal Kisah Asmara Ben Sihombing dan Cindercella

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Boundaries (insulators) in the Drosophila bithorax complex (BX-C) delimit autonomous regulatory domains that orchestrate the parasegment (PS)-specific expression of the BX-C homeotic genes.

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To find the domain of a function, consider any restrictions on the input values that would make the function undefined, including dividing by zero, taking the square root of a negative number, or taking the logarithm of a negative number. Remove these values from the set of all possible input values to find the domain of the function.

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Multimerization and DNA-binding activity of Insv Insv protein sequences required for DNA binding. DNA binding by the Elba BEN domain proteins, Elba1 and Elba2, requires a third protein, Elba3, to link them together [].In contrast, we found that Insv expressed by in vitro translation in rabbit reticulocyte lysates is able to bind CCAATTGG palindrome without the addition of any co-factors [].

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The BEN domain is a recently recognized DNA binding module that is present in diverse metazoans and certain viruses. Several BEN domain factors are known as transcriptional repressors, but, overall, relatively little is known of how BEN factors identify their targets in humans. In particular, X-ray structures of BEN domain:DNA complexes are.

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We recently reported that Drosophila Insensitive (Insv) promotes sensory organ development and has activity as a nuclear corepressor for the Notch transcription factor Suppressor of Hairless [Su(H)]. Insv lacks domains of known biochemical function but contains a single BEN domain (i.e., a "BEN-solo.

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Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or.

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We report a previously uncharacterized α-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod (mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein.

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Enter the Function you want to domain into the editor. The domain calculator allows you to take a simple or complex function and find the domain in both interval and set notation instantly. Step 2: Click the blue arrow to submit and see the result! The domain calculator allows to find the domain of functions and expressions and receive results.

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To develop a strategy to utilize AI-predicted protein structures for domain annotation, we chose the BEN domain as a model. Bioinformatics and crystallographic analyses indicate that the BEN domain contains five or six α helices with a long middle loop, ranging from 13 aa in BEND3-BEN4 to 28 aa in PG067-BEN1 of Vaccinia virus, between the α3 and α4 helices (Figures 1 A-1D). 6, 16 In.

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We recently reported that Drosophila Insensitive (Insv) promotes sensory organ development and has activity as a nuclear corepressor for the Notch transcription factor Suppressor of Hairless [Su(H)]. Insv lacks domains of known biochemical function but contains a single BEN domain (i.e., a "BEN-solo" protein). Our chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq) analysis.

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The structural deorphanization of LIN-14 as a BEN domain-containing protein provides new vistas on both LIN-14 protein function as well as BEN domain proteins in general. Since many BEN domain proteins are involved in controlling chromatin architecture, it is conceivable that, in addition to transcriptional regulation, LIN-14 may also play a.

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